Cavener Lab 113 Life Sciences Building, University Park, PA 16802

Selected Publications:

Hao, S., Sharp, J. W., Ross-Inta, C. M., McDaniel, B. J., Anthony, T. G., Wek, R. C., Cavener, D. R., McGrath, B. C., Rudell, J. B., Koehnle, T. J. and Gietzen, D. W. (2005) Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex. Science 307, 1776-8

Liu, M., Li, Y., Cavener, D. and Arvan, P. (2005) Proinsulin disulfide maturation and misfolding in the endoplasmic reticulum. J. Biol. Chem.

Anthony, T. G., McDaniel, B. J., Byerley, R. L., McGrath, B. C., Cavener, D. R., McNurlan, M. A. and Wek, R. C. (2004) Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2. J. Biol. Chem. 279, 36553-61

Jiang, H. Y., Wek, S. A., McGrath, B. C., Lu, D., Hai, T., Harding, H. P., Wang, X., Ron, D., Cavener, D. R. and Wek, R. C. (2004) Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response. Mol. Cell Biol. 24, 1365-77

Iida, K. and Cavener, D. R. ( 2004) Glucose dehydrogenase is required for normal sperm storage and utilization in female Drosophila melanogaster. J Exp Biol 207, 675-81

Li, Y., Iida, K., O'Neil, J., Zhang, P., Li, S., Frank, A., Gabai, A., Zambito, F., Liang, S. H., Rosen, C. J. and Cavener, D. R. (2003) PERK eIF2alpha kinase regulates neonatal growth by controlling the expression of circulating insulin-like growth factor-I derived from the liver. Endocrinology 144, 3505-13

Jiang, H. Y., Wek, S. A., McGrath, B. C., Scheuner, D., Kaufman, R. J., Cavener, D. R. and Wek, R. C. (2003) Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses. Mol. Cell Biol. 23, 5651-63

Zhang, P., McGrath, B. C., Reinert, J., Olsen, D. S., Lei, L., Gill, S., Wek, S. A., Vattem, K. M., Wek, R. C., Kimball, S. R., Jefferson, L. S. and Cavener, D. R. (2002) The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice. Mol. Cell Biol. 22, 6681-8

Zhang, P., McGrath, B., Li, S., Frank, A., Zambito, F., Reinert, J., Gannon, M., Ma, K., McNaughton, K. and Cavener, D. R. (2002) The PERK Eukaryotic Initiation Factor 2alpha Kinase Is Required for the Development of the Skeletal System, Postnatal Growth, and the Function and Viability of the Pancreas. Mol. Cell Biol. 22, 3864-3874

Kumar R, Azam S, Sullivan JM, Owen C, Cavener DR, Zhang P, Ron D , Harding HP, Chen J-J, Han A, White BC, Krause GS and DeGracia DJ. (2001) Brain ischemia and reperfusion activates the eukaryotic initiation factor 2alpha kinase, PERK. Journal of Neurochemistry 77, 1-5

Keplinger, B. L., Guo, X., Quine, J. A., Feng, Y. and Cavener, D. R. (2001) Complex organization of promoter and enhancer elements regulate the developmental genetics.

Sood, R., Porter, A. C., Olsen, D. A., Cavener, D. R. and Wek, R. C. (2000) A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alpha. Genetics 154, 787-801

Olsen, D. S., Jordan, B., Chen, D., Wek, R. C. and Cavener, D. R. (1998) Isolation of the gene encoding the Drosophila melanogaster homolog of the Saccharomyces cerevisiae GCN2 eIF-2alpha kinase. Genetics 149, 1495-509

Ye, X., Fong, P., Iizuka, N., Choate, D. and Cavener, D. R. (1997) Ultrabithorax and Antennapedia 5' untranslated regions promote developmentally regulated internal translation initiation. Mol. Cell Biol. 17, 1714-21

Qu, S., Perlaky, S. E., Organ, E. L., Crawford, D. and Cavener, D. R. (1997) Mutations at the Ser50 residue of translation factor eIF-2alpha dominantly affect developmental rate, body weight, and viability of Drosophila melanogaster. Gene Expr 6, 349-60

Keplinger, B. L., Rabetoy, A. L. and Cavener, D. R. (1996) A somatic reproductive organ enhancer complex activates expression in both the developing and the mature Drosophila reproductive tract. Dev Biol 180, 311-23

Duncan, R. F., Cavener, D. R. and Qu, S. (1995) Heat shock effects on phosphorylation of protein synthesis initiation factor proteins eIF-4E and eIF-2 alpha in Drosophila. Biochemistry 34, 2985-97

Yaich, L., Roodi, N., Bailey, L. R., Verrier, C. S., Yee, C. J., Cavener, D. R. and Parl, F. F. (1995) Analysis of estrogen receptor gene, transcript and protein in ER-positive and ER-negative breast cancer cell lines. Endocrine-Related Cancer 2, 293-309

Ye, X. and Cavener, D. R. (1994) Isolation and characterization of the Drosophila melanogaster gene encoding translation-initiation factor eIF-2 beta. Gene 142, 271-4

Gunaratne, P., Ross, J. L., Zhang, Q., Organ, E. L. and Cavener, D. R. (1994) An evolutionarily conserved palindrome in the Drosophila Gld promoter directs tissue-specific expression. Proc. Natl. Acad. Sci. U.S.A. 91, 2738-42

Qu, S. and Cavener, D. R. (1994) Isolation and characterization of the Drosophila melanogaster eIF-2 alpha gene encoding the alpha subunit of translation initiation factor eIF-2. Gene 140, 239-42

Ross, J. L., Fong, P. P. and Cavener, D. R. (1994) Correlated evolution of the cis-acting regulatory elements and developmental expression of the Drosophila Gld gene in seven species from the subgroup melanogaster. Dev Genet 15, 38-50

Quine, J. A., Gunaratne, P., Organ, E. L., Cavener, B. A. and Cavener, D. R. (1993) Tissue-specific regulatory elements of the Drosophila Gld gene. Mech Dev 42, 3-13

Cavener, D. R. and Cavener, B. A. (1993) Translation start sites and mRNA leaders. 359-377

Schiff, N. M., Feng, Y., Quine, J. A., Krasney, P. A. and Cavener, D. R. (1992) Evolution of the expression of the Gld gene in the reproductive tract of Drosophila. Mol Biol Evol 9, 1029-49

Schonbaum, C. P., Organ, E. L., Qu, S. and Cavener, D. R. (1992) The Drosophila melanogaster stranded at second (sas) gene encodes a putative epidermal cell surface receptor required for larval development. Dev Biol 151, 431-45

Cavener, D. R. (1992) Transgenic animal studies on the evolution of genetic regulatory circuitries. Bioessays 14, 237-44

Cavener, D. R. (1992) GMC oxidoreductases. A newly defined family of homologous proteins with diverse catalytic activities. J. Mol. Biol. 223, 811-4

Yaich, L., Dupont, W. D., Cavener, D. R. and Parl, F. F. (1992) Analysis of the PvuII restriction fragment-length polymorphism and exon structure of the estrogen receptor gene in breast cancer and peripheral blood. Cancer Res 52, 77-83

Feng, Y., Schiff, N. M. and Cavener, D. R. (1991) Organ-specific patterns of gene expression in the reproductive tract of Drosophila are regulated by the sex-determination genes. Dev Biol 146, 451-60

Foster, B. D., Cavener, D. R. and Parl, F. F. (1991) Binding analysis of the estrogen receptor to its specific DNA target site in human breast cancer. Cancer Res 51, 3405-10

Cavener, D. R. and Ray, S. C. (1991) Eukaryotic start and stop translation sites. Nucleic Acids Res 19, 3185-92

Feng, Y., Gunter, L. E., Organ, E. L. and Cavener, D. R. (1991) Translation initiation in Drosophila melanogaster is reduced by mutations upstream of the AUG initiator codon. Mol. Cell Biol. 11, 2149-53

Cavener, D. R. and Krasney, P. A. (1991) Drosophila glucose dehydrogenase and yeast alcohol oxidase are homologous and share N-terminal homology with other flavoenzymes. Mol Biol Evol 8, 144-150

Cavener Lab 2005