Publications from Penn State

2016

Demers M, Wong SL, Martinod K, Gallant M, Cabral JE, Wang Y, Wagner DD (2016) Priming of neutrophils toward netosis promotes tumor growth. OncoImmunology. 5(5):e1134073.
 DOI:10.1080/2162402X.2015.1134073

Vollger L, Akong-Moore K, Cox L, Goldmann O, Wang Y, Schafer S, Naim H, Nizet V, von Kockritz-Blickwede M (2016) Iron chelating agents desferrioxamine and L-mimosine stimulate neutrophil extracellular traps (NETs) 36(3). pii: e00333. DOI: 10.1042/BSR20160031.

Klionsky DJ et al. …Wang Y… (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12(1):1-222.

Tohme S, Yazdani HO, Al-Khafaji AB, Chidi AP, Lougharn P, Mowen K, Wang Y, Simmons RL, Huang H, Tsung A. (2016) Neutrophil Extracellular Traps Promote the Development and Progression of Liver Metastases after Surgical Stress. Cancer Res. 76:1367-1380.

2015

Zhang L, Yin JC, Yeh H, Ma NX, Lee G, Chen XA, Wang Y, Lin L, Jin P, Wu GY, Chen G. Small molecules efficiently reprogram human astroglial cells into functional neurons. (2015) Cell Stem Cell. 17:735-747. PMID: 26481520

He W, Zhou P, Chang Z, Liu B, Liu X, Wang Y, Li Y, Alam HB. Inhibition of peptidylarginine deiminase attenuates inflammation and improves survival in a rat model of hemorrhagic shock. (2015) Journal of Surgical Research. 200:610-618. PMID: 26434505

Wong SL, Martinod K, Demers M, Gallant M, Wang Y, Kahn CR, and Wagner DD (2015) Diabetes primes neutrophils to undergo NETosis which severely impairs wound healing. Nature Medicine 21:815-819. PMCID: PMC4631120

Wang S, Chen XA, Hu J, Jiang JK, Li Y, Chan-Salis KY, Gu Y, Chen G, Thomas C, Pugh BF, and Wang Y (2015) ATF4 gene network mediate cellular response to the anticancer PAD4 inhibitor YW3-56. Molecular Caner Therapeutics 14:877-888. PMID: 25612620

Huang H, Thome S, Al-Khafaji AB, Tai S, Loughran P, Chen L, Kim J, Billiar T, Wang Y, Tsung A (2015) DAMPs-activated neutrophil extracellular trap exacerbates sterile inflammatory liver injury.  Hepatology. 62:600-614. PMID: 25855125

Chen XA, Sun J, Wang Y. (2015) Techniques Analyzing Chromatin Modifications at Specific Loci. Epigenetic Technological Applications. 79-103.  

Martinod K, Fuchs TA, Wong SL, Demers M, Gallant M, Wang Y, Wagner DD (2015) PAD4-deficiency does not worsen polymicrobial sepsis mortality and ameliorates endotoxemia. Blood 125:1948-56. PMID: 25624317

Sabulski MJ, Wang Y, Pires MM (2015) PAD2 activity monitored via a fluorescent substrate analog. Chemical Biology & Drug Design. 86:599-605. PMID: 25643806

2014

Chang GS, Chen XA, Park B, Rhee HS, Li P, Han KH, Mishra T, Chan-Salis KY, Li Y, Hardison RC, Wang Y, Pugh BF. (2014) A comprehensive and high-resolution genome-wide response of p53 to stress. Cell Rep 8:514-27.

Li Y, Liu Z, Liu B, Zhao T, Chong W, Wang Y, Alam HB.(2014) Citrullinated hisotne H3: a novel target for the treatment of sepsis. Surgery 156:229-34.

Jerjomiceva N, Seri H, Vollger L, Wang Y, Zeitouni N, Naim HY, von Kockritz-Bickwede M (2014) Enrofloxacin enhances the formation of neutrophil extracellular traps in bovine granulocytes. J. Innate Immunity. 6:706-12.

Shelef MA, Sokolove J, Lahey LJ, Wagner CA, Sackmann EK, Warner TF, Wang Y, Beebe DJ, Robinson WH, Huttenlocher A (2014) Peptidylarginine deiminase 4 contributes to tumor necrosis factor alpha induced inflammatory arthritis. Arthritis & Rheumatism. 66:1482-91.

Savchenko AS, Borissoff JI, Martinod K, De Meyer SF, Gallant M, Erpenbeck L, Brill A, Wang Y, Wagner DD (2014) VWF-mediated leukocyte recruitment with chromatin decondensation by PAD4 increases myocardial ischemia/reperfusion injury in mice. Blood 23:141-8.

2013

Savchenko AS, Borissoff JI, Martinod K, De Meyer SF, Gallant M, Erpenbeck L, Brill A, Wang Y, Wagner DD. (2013) VWF-mediated leukocyte recruitment with chromatin decondensation by PAD4 increases myocardial ischemia/reperfusion injury in mice. Blood 123:141-8.

Wang S and Wang Y (2013) Peptidylarginine deiminase in citrullination, gene regulation, health and pathogenesis. Biochim Biophys Acta 1829:1126-1135.

Martinod K, Demers M, Fuchs TA, Wong SL, Brill A, Gallant M, Hu J, Wang Y, Wagner DD (2013) Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis. Proc. Natl. Acad. Sci. 110:8674-9.

Hu J and Wang Y (2013) p53 and the PWWP domain containing effector proteins in chromatin damage repair.  Cell Dev Biol 2:112.doi:10.4172/2168-9296.1000112 (Invited review)

Zhu H, Wang Y, Wang Y, Zhao S, Zhao M*, Gui L, Xu W, Chen XA, Wang Y*, Peng S* (2013) Folded conformation, cyclic pentamer, nano-structure and PAD4 binding mode of YW3-56. Journal of Physical Chemistry C. 117:10070-10078. (*authors of correspondence)

2012

Wang Y *, Li P*, Wang S*, Hu J, Chen XA, Wu J, Fisher M, Oshaben K, Zhao N, Gu Y, Chen G#, Wang Y#. (2012) Anticancer PAD inhibitors regulate autophagy and the mammalian target of rapamycin complex 1 activity. Journal of Biological Chemistry. 287:25941-53. (*authors of equal contribution, # authors of correspondence)

Hu J*, Yao H*, Gan F, Tokarski A, and Wang Y. (2012) Coordination of OKL38 and p53 in apoptosis induction by regulating mitochondria morphology and function. PLoS ONE 7(8):e43362. (*authors of equal contribution).

Leshner M, Wang S, Lewis C, Zheng H, Chen XA,Santy L, and Wang Y. (2012) PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures. Frontiers in Immunology 3:307.

Xu L, Hu J, Zhao Y, Hu J, Xiao J, Wang Y, Ma D, and Chen Y. (2012) PDCD5 interacts with p53 and functions as a positive regulator in the p53 pathway. Apoptosis 17:1235-1245.

Shi K, Edwards PS, Hu J, Xu Q, Wang Y, Psaltis D, and Liu Z. (2012) Holographic coherent anti-stokes raman scattering bio-imaging. Biomedical Optics Express 3:1744-1749.

Li P, Hu J, and Wang Y. (2012) Methods for analyzing histone citrullination in chromatin structure and gene regulation. Methods in Molecular Biology 809:473-488.

2011

Wu L, Zee BM, Wang Y, Garcia BA, and Dou Y. (2011) The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 ubiquitylation and is important for H3 K4/K79 methylation and transcription activation. Molecular Cell 43:132-144.

Wu H, Zeng H, Lam R, Tempel W, Amaya MF, Xu C, Dombrovski L, Qiu W, Wang Y, and Min J. (2011) Structural and histone binding ability characterizations of human PWWP domains. PloS ONE 6(6): e18919.

Liu Y, Chan YM, Wu J, Chen C, Benesi A, Hu J, Wang Y, and Chen G. (2011) Chemical Synthesis of a bisphosphorylated mannose-6-phosphate N-glycan and its facile monoconjugation with human carbonic anhydrase II for in vivo fluorescence imaging. Chembiochem. 12:685-690.

Joo HY, Jones A, Yang C, Zhai L, Smith AD, Zhagn Z, Chandrasekharan MB, Sun ZW, Renfrow M, Wang Y, Chang C, and Wang H. (2011) Regulation of histone H2A and H2B deubiquitination and Xenopus development by USP12 and USP46. Journal of Biological Chemistry 286:7190-7201.

2010

Li P, Li M, Lindberg MR, Kennett MJ, Xiong N, and Wang Y. (2010) PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps. Journal of Experimental Medicine 207:1853-62.

Li P, Wang D, Yao H, Doret P, Hao G, Shen Q, Qiu H, Zhang X, Wang Y, Chen G, and Wang Y. (2010) Coordination of PAD4 and HDAC2 in the regulation of p53 target gene expression. Oncogene 29:3153-62.

Jin Y, Xia M, Saylor CM, Narayan K, Kang J, Wiest DL, Wang Y, and Xiong N. (2010) Intrinsic programming of thymic T cells for specific peripheral tissue localization. Journal of Immunology. 185:7156-7160.

Chow, O.A., von Kockritz-Blickwede, M., Bright, A.T., Hensler, M.E., Zinkernagel, A.S., Cogen, A.L., Gallo, R.L., Monestier, M., Wang, Y., Glass, C.K., and Nizet, V. (2010) Statins enhance formation of phagocyte extracellular traps. Cell Host & Microbe 18:445-454.

2009

Wang Y*, Li M, Stadler S, Correll S, Li P, Wang D, Hayama R, Leonelli L, Han H, Grigoryev S, Allis CD, and Coonrod SA* (2009) Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation. Journal of Cell Biology 184:205-13.  (*correspondence authors).

Hao G, Wang D, Gu J, Shen Q, Gross SS, and Wang Y. (2009) Neutral loss of isocyanic acid in peptide CID spectra: a novel diagnostic marker for mass spectrometry identification of protein citrullination. Journal of American Society of Mass Spectrometry. 20:723-7.

Prior to 2008

Li P, Yao H, Zhang Z, Li M, Luo Y, Thompson PR, Gilmour DS, and Wang Y. (2008) Regulation of p53 target gene expression by peptidylarginine deiminase 4. Molecular and Cellular Biology 28:4745-58.

Yao H, Li P, Venters BJ, Zheng S, Thompson PR, Pugh BF, and Wang Y. (2008) Histone Arg modifications and p53 regulate the expression of OKL38, a mediator of apoptosis. Journal of Biological Chemistry 283:20060-8.

Wang, Y. (2006) Methylation and demethylation of histone Lys and Arg residues in chromatin structure and function. In the ENZYMES protein methyltransferases XXIV, 123-153.

Publications of postdoctoral work

Wang Y, Wysocka J, Sayegh J, Lee YH, Perlin JR, Leonelli L, Sonbuchner LS, McDonald CH, Cook RG, Dou Y, Roeder RG, Clarke S, Stallcup MR, Allis CD*, and Coonrod SA*. (2004) Human PAD4 regulates histone arginine methylation levels via demethylimination. Science 306:279-83. (*correspondence authors; cited 438 times)

Wang Y, Wysocka J, Perlin JR, Leonelli L, Allis CD, and Coonrod SA. (2004) Linking histone modifications to epigenetics: the rigidity and plasticity of the marks. The 69th Cold Spring Harbor Symposium on Quantitative Biology, 161-170.

Wang Y, Fischle W, Cheung W, Jacobs S, Khorasanizadeh S, and Allis CD. (2004) Beyond the double helix: writing and reading the histone code. In: Reversible protein acetylation. Novartis Found Symp, 259:3-20 Wiley, Chichester.

Sarmento OF, Digilio LC, Wang Y, Perlin J, Herr JC, Allis CD, and Coonrod, SA. (2004) Dynamic alterations of specific histone modifications during early murine development. J Cell Sci. 117:4449-59.

Barber CM, Turner FB, Wang Y, Hagstrom K, Taverna SD, Mollah S, Ueberheide B, Meyer BJ, Hunt DF, Cheung P, and Allis CD. (2004) The enhancement of histone H4 and H2A serine 1 phosphorylation during mitosis and S-phase is evolutionarily conserved. Chromosoma 112:360-71.

Fischle W*, Wang Y*, Jacobs SA*, Kim Y, Allis CD, and Khorasanizadeh S. (2003) Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by polycomb and HP1 chromodomains. Genes Dev. 17:1870-81. (*authors of equal contribution)

Fischle W, Wang Y, and Allis CD. (2003) Binary switches and modification cassettes in histone biology and beyond. Nature 425:475-9.

Fischle W*, Wang Y*, and Allis CD. (2003) Histone and Chromatin Cross-talk.  Curr. Opin. Cell Biol. 15:172-83. (*authors of equal contribution)

Nishioka K, Rice JC, Sarma K, Erdjument-Bromage H, Werner J, Wang Y, Chuikov S, Valenzuela P, Tempst P, Steward R, Lis JT, Allis CD, and Reinberg D. (2002) PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin. Mol. Cell 9:1201-13.

Publications of graduate work

Wang Y, Zhang W, Jin Y, Johansen J, and Johansen KM. (2001) The JIL-1 tandem kinase mediates histone H3 phosphorylation and is required for maintenance of chromatin structure in Drosophila. Cell 105:433-43.

Bao X, Zhang W, Krencik R, Deng H, Wang, Y, Girton J, Johansen J, and Johansen KM. (2005) The JIL-1 kinase interacts with lamin Dm0 and regulates nuclear lamina morphology of Drosophila nurse cells. J. Cell Sci. 118:5079-87.

Zhang W, Wang Y, Long J, Girton J, Johansen J, and Johansen KM. (2003) A developmentally regulated splice-variant from the complex lola locus encoding multiple different zinc-finger domain proteins interacts with the chromosomal kinase JIL-1. J. Biol. Chem. 278:11696-704.

Jin Y *, Wang Y *, Johansen J, and Johansen KM. (2000) JIL-1, a chromosomal kinase implicated in regulation of chromatin structure, associates with the MSL dosage compensation complex. J. Cell Biol. 149:1005-10. (*authors of equal contribution)

Walker DL, Wang D, Jin Y, Rath U, Wang Y, Johansen J, and Johansen KM. (2000) Skeletor, a novel chromosomal protein that redistributes during mitosis provides evidence for the formation of a spindle matrix. J. Cell Biol. 151:1401-12.

Jin Y, Wang Y, Walker DL, Dong H, Conley C, Johansen J, and Johansen KM. (1999) JIL-1: A novel chromosomal tandem kinase implicated in transcriptional regulation in Drosophila. Mol. Cell 4:129-35.

Johansen KM, Johansen J, Jin Y, Walker DL, Wang D, and Wang Y. (1999) Chromatin structure and nuclear remodeling. Crit Rev Eukaryot Gene Expr. 9:267-77.